Melphalan CAS 148-82-3

CAS Number

148-82-3

Grade

Highly Purified

MDL Number

MFCD00057717

Molecular Formula

C13H18Cl2N2O2

Molecular Weight

305.2

EU Commodity Code

38220090

Shipping Temp

Storage Temp

-20°C

4-[Bis(2-chloroethyl)amino]-L-phenylalanine; p-Di-(2-chloroethyl)amino-L-phenylalanine; L-phenylalanine Mustard; Alanine Nitrogen Mustard; L-PAM; Melfalan; Alkeran; Sarcoclorin

Antineoplastic. Nitrogen mustard derivative; DNA crosslinking agent; anti-cancer agent

Synonyms

4-[Bis(2-chloroethyl)amino]-L-phenylalanine; p-Di-(2-chloroethyl)amino-L-phenylalanine; L-phenylalanine Mustard; Alanine Nitrogen Mustard; L-PAM; Melfalan; Alkeran; Sarcoclorin

CAS No

148-82-3

Molecular Formula

C13H18Cl2N2O2

Molecular Weight

305.20

Appearance

White to off-white solid

Purity

≥93%

Melting Point

180°C

Method for Determining Identity

Proton NMR Spectroscopic and Mass Spectrometric Analysis

Water

≤5%

Solubility

Aqueous Acid (Slightly), Methanol (Slightly)

Storage and Stability

May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

References

Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966), Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980)