Menaquinone 4 CAS 863-61-6

CAS Number

863-61-6

Grade

Purified

Molecular Formula

C31H40O2

Molecular Weight

444.7

EU Commodity Code

38220090

Shipping Temp

Storage Temp

-20°C

(E,E,E)-2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthalenedione; Menatetrenone; Vitamin K2(20); Kaytwo; MK 4

Menaquinone 4 (MK-4) is the predominant homolog of vitamin K2 and is composed of a naphthoquinone base with four isoprenoid units in the side chain.1 It is formed primarily via conversion of vitamin K1 (Item No. 21051) in vivo and accumulates in various tissues, including the brain.2,3 MK-4 halts the cell cycle at the G phase in HepG2, Hep3B, and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner.4 It also inhibits I?B kinase (IKK) activity, I?Ba phosphorylation, and the transcriptional activity of NF-?B. Vitamin K2 may have a role in bone metabolism.1

Synonyms

(E,E,E)-2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthalenedione; Menatetrenone; Vitamin K2(20); Kaytwo; MK 4

CAS Number

863-61-6

Molecular Weight

444.7

Molecular Formula

C31H40O2

Appearance

White to off-white to yellow solid

Purity

≥98%

Storage and Stability

Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Melting Point: 35°C

Storage and Stability

May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

References

1. Plaza, S.M., and Lamson, D.W. Vitamin K2 in bone metabolism and osteoporosis. Altern. Med. Rev. 10(1), 24-35 (2005).|2. Shearer, M.J., and Newman, P. Metabolism and cell biology of vitamin K. Thromb. Haemost. 100(4), 530-547 (2008).|3. Okano, T., Shimomura, Y., Yamane, M., et al. Conversion of phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) in mice: Two possible routes for menaquinone-4 accumulation in cerebra of mice. J. Biol. Chem. 283(17), 11270-11279 (2008).|4. Ozaki, I., Zhang, H., Mizuta, T., et al. Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor κB activation. Clin. Cancer Res. 13(7), 2236-2245 (2007).

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M2876 Menaquinone 4 (Vitamin K2 (20), MK 4) CAS: 863-61-6

CAS Number

Grade

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

(E,E,E)-2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthalenedione; Menatetrenone; Vitamin K2(20); Kaytwo; MK 4

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USBio References

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