Methylprednisolone CAS 83-43-2

CAS Number

83-43-2

Grade

Highly Purified

Molecular Formula

C22H30O5

Molecular Weight

374.47

EU Commodity Code

38220090

Shipping Temp

Storage Temp

-20°C

(6α,11β)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione; Medrone; Medrol; Medrate

A glucocorticoid which displays anti-inflamatory and antioxidant properties and attenuates apoptosis in oligodendrocytes after injury. 6α-Methyl Prednisolone is neuroprotective.

CAS No

83-43-2

Molecular Formula

C₂₂H₃₀O₅

Molecular Weight

374.47

Melting Point

>206ºC (dec.)

Solubility

Acetone (Slightly), Chloroform (Slightly, Heated), Dioxane (Sparingly, Sonicated)

Appearance

White to Off-White Solid

Method for Determining Identity

Proton NMR Spectroscopic Analysis

TLC Conditions

SiO2; Dichloromethane: Methanol: 9: 1; Visualized with UV and KMNO4; Single spot; Rf=0.4

Storage and Stability

May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards

All products should be handled by qualified personnel only, trained in laboratory procedures.

References

1. Hall, E.D., et al.: J. Neurosurg., 76, 13 (1992). 2. Hommes, O.R., et al.: Mult. Scler., 1, 327 (1996). 3. Bracken, M.B., et al.: J. Neurosurg., 89, 699 (1998). 4. Dammers, J.W.H.H., et al.: Brit. Med. J., 319, 884 (1999).