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N0547-35B Goat Anti-Neurochondrin (NCDN, KIAA0607)

Specifications
References
Clone Type
Polyclonal
Host
Goat
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E
Crossreactivity
Bo Ca Hu Mo Rt
Accession #
NP_055099.1, NP_001014841.1
Gene ID
23154, 26562, 89791
Shipping Temp
Blue Ice
Storage Temp
-20°C

Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca2+-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.

Applications
Suitable for use in ELISA. Other applications not tested.
Recommended Dilution
ELISA: 1:16,000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to C-HYLLQVGSEKQKEP, from NCDN, at the internal region of the protein (NP_055099.1, NP_001014841.1).
Form
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes NCDN. Species sequence homology: Bovine, canine, human, mouse and rat.
References
1. Dateki M, Horii T, Kasuya Y, Mochizuki R, Nagao Y, Ishida J, Sugiyama F, Tanimoto K, Yagami K, Imai H, Fukamizu A. Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure. J Biol Chem. 2005 May 27;280(21):20503-8. Epub 2005 Mar 24.
USBio References
No references available
Conjugates
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