(3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide; AG 1341
An antiviral. Labeled HIV protease inhibitor.
Synonyms
(3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide; AG 1341
CAS No
1217629-70-3 159989-64-7-unlabelled
Molecular Formula
C₃₂H₄₂D₃N₃O₄S
Molecular Weight
570.8
Purity
≥95%
Appearance
Supplied as a white solid
Melting Point
187-190°C
Solubility
DMSO (Slightly), Methanol (Slightly)
Atmosphere
Inert Gas
Method for Determining Identity
Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions
SiO2; Dichloromethane: Methanol=9:1; Visualized with UV and AMCS; Single Spot, Rf=0.65
Normalized Intensity
d0=0.03%, d1=0.71%, d2=2.25%, d3=97.01%
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt.. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Store under inert atmosphere.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Source
Synthetic
Purity
≥95%
Form
Supplied as a white solid
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Patick, A.K., et al.: Antimicrol Ag. Chemother., 40, 292 (1996). 2. Bardsley-Elliot, G.L., et al.: Drugs, 59, 581 (2000)