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N8575 Nystatin CAS: 1400-61-9

Specifications
References
CAS Number
1400-61-9
Grade
USP
Molecular Formula
C₄₇H₇₅NO₁₇
Molecular Weight
962.1
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
Nystatin A1; Mycostatin; Fungicidin

Nystatin is a mixture of the byproducts of Streptomyces noursei. Nystatin belongs to the group of medicines called antifungals. Nystatin works by binding to a substance called ergosterol, which is a component of fungal cell membranes. Binding to ergosterol disrupts the cell membrane and causes holes to appear.

Synonyms
Nystatin A1; Mycostatin; Fungicidin
CAS No
1400-61-9
Molecular Formula
C₄₇H₇₅NO₁₇
Molecular Weight
962.1
Appearance
Off-white to yellowish powder
Activity
≥4400u/mg
Melting Point
>160°C
Loss on Drying
≤5%
pH (3%)
6-8
Residual Solvents
Methanol: ≤3% Acetone: ≤5%
Suspendibility, Crystallinity, Identification and Composition
To pass test
Storage and Stability
Lyophilized product is stable for 12 months after receipt at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Stable for 1 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
References
1. Brezis, M., Science 224: 66 (1984). 2. Brautaset, T., et al.: Chem. Biol., 7, 395 (2000). 3. Brautaset, T., et al.: J. Biol. Chem., 278, 14913 (2003). 4. Bruheim, P., et al.: Antimicrob. Agents Chemother., 48, 4120 (2004). 5.Scott, L., et al.: Drugs, 67, 269 (2007)
USBio References
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