Oligomycin B CAS 11050-94-5

CAS Number

11050-94-5

Grade

Highly Purified

Molecular Formula

C45H72O12

Molecular Weight

805.1

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Oligomycin B, a minor component of the oligomycin complex isolated from selected strains of Streptomyces sp., is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death and also leads to a switch in the death mode from apoptosis to necrosis.

Related to

Oligomycin A, Oligomycin C, 21-hydroxyoligomycin A

Solubility

Soluble in ethanol, methanol, DMF or DMSO.

Storage and Stability

For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Source

Streptomyces sp.

Purity

~ 95% by HPLC

Form

Supplied as a white solid.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Miyoshi N. et al. Proc. Natl Acad. Sci. USA 2006, 103, 1727. 2. Mitochondria in eosinophils: functional role in apoptosis but not respiration. Peachman K.K. et al. Proc. Natl Acad. Sci. USA 2001, 98, 1717. 3. The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin. Fitch M.E. et al. Cell Death Differ. 2000, 7, 338..

USBio References

No references available

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O6154-01 Oligomycin B CAS: 11050-94-5

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