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O8053-40 Oseltamivir Acid CAS: 187227-45-8

Specifications
References
CAS Number
187227-45-8
Grade
Highly Purified
MDL Number
MFCD00953940
Molecular Formula
C14H24N2O4
Molecular Weight
284.35
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
(3R,4R,5S)-4-(Acetylamino)-5-amino-3-(1-ethylpropoxy)-1-cyclohexence-1-carboxylic Acid; Oseltamivir Carboxylic Acid; GS 4071; Ro 64-0802; Oseltamivir Carboxylate

A metabolite of Oseltamivir. Inhibitor of viral neuraminidase enzyme, effective against influenza A and B viruses. This antiviral compound inhibits neuraminidase-mediated cleavage of host cell sialic acids, which interact with newly synthesised virions from the host cell. This prevents virion budding from the host, resulting in inhibition of virion release and viral infection overall.

Synonyms
(3R,4R,5S)-4-(Acetylamino)-5-amino-3-(1-ethylpropoxy)-1-cyclohexence-1-carboxylic Acid; Oseltamivir Carboxylic Acid; GS 4071; Ro 64-0802; Oseltamivir Carboxylate
CAS No
187227-45-8
Molecular Formula
C14H24N2O4
Molecular Weight
284.35
Purity
≥98% (HPLC)
Appearance
White to off-white powder
Water
≤5%
Specific Rotation (C=0.5, water)
-24.0 to -30.0º
Identity (1H NMR)
Conforms to structure
Melting Point
187ºC (lit)
Storage and Stability
Store at -20ºC. Stable for 6 months after receipt.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Oliyai, R., et al., Pharm. Res., 15, 1300 (1998). 2. Kim, C.U., et al., Med. Chem. Res., 8, 392 (1998). 3. Hayden, F.G., et al., N. Engl. J. Med., 341, 1336 (1999). 4. Treanor, J.J., et al., J. Am. Med. Assoc., 283, 1016 (2000)
USBio References
1. Kim, M. et al., (2013) Antiviral Research, http://dx.doi.org/10.1016/j.antiviral.2013.08.002. |2. Kim, M. et al., (2012) Antiviral Research 93; 253-259.|3. Dao NT, et al. Chemical Constituents and Anti-influenza Viral Activity of the Leaves of Vietnamese Plant Elaeocarpus tonkinensis. 2019. Rec. Nat. Prod. 13(1):71-80. http://www.acgpubs.org/doc/2018100820135976-RNP-1804-266.pdf
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