Desmethyl Erlotinib, Free Base CAS 183321-86-0

CAS Number

183321-86-0

Grade

Highly Purified

Molecular Formula

C21H21N3O4

Molecular Weight

379.41

EU Commodity Code

38220090

Shipping Temp

Storage Temp

-20°C

2-[[4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]ethanol; OSI-420; CP 373420

A metabolite of Erlotinib, an anti cancer agent.

Form

Supplied as an off-white solid.

Purity

~90%

Melting Point

Transition: 81-97ºC Melting:140-142ºC

Solubility

DMSO, methanol

Method for Determining Identity

Proton NMR Spectroscopic Analysis

TLC Conditions

SiO2; Dichloromethane: Methanol; 9:1; Visualized with UV and KMnO4; Single spot; Rf=0.55.

Storage and Stability

May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Source

Synthetic

Purity

~90%

Form

White to Off-White Solid

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

Rusch, V., et al.: Cancer Res., 53, 2379 (1993), Fontanini, G., et al.: Clin. Cancer Res., 4, 241 (1998), Comis, R., et al.: Oncologist, 10, 467 (2005), Ling, J., et al.: Drug Metab. Dispos., 34, 420 (2006