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P1792A Paclitaxel (Taxol) CAS: 33069-62-4

Specifications
References
CAS Number
33069-62-4
Grade
Highly Purified
MDL Number
MFCD00869953
Molecular Formula
C47H51NO14
Molecular Weight
853.91
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
Abraxane; Genaxol; Genetaxyl; OncoGel; Onxal; Pacliex; (-)-Paclitaxel; Taxol; Yewtaxan; NSC 125973

Antitumor and antileukemic agent isolated from the bark of the yew tree, Taxus brevifolia.

Synonyms
Soluble
CAS No
33069-62-4
Molecular Formula
C47H51NO14
Molecular Weight
853.91
Appearance
White powder
Purity
HPLC: ~99% TLC: ~99%
Solubility
Soluble in DMSO at 200mg/ml; soluble in ethanol at 40mg/ml; very poorly soluble in water; maximum solubility in water is ~10-20uM; buffers, serum or other additives may increase or decrease the aqueous solubility.
Melting Point
>212°C (dec.)
Calculated
C: 64.74% H: 6.13% N: 1.61%
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. Wani, M.C., et al. "Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia." J. Am. Chem. Soc. 93:2325-2327 (1971). 2. McGuire, W.P., et al. "Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms" Ann. Int. Med. 111:273-279 (1989). 3. Rowinsky, E.K., et al. "Taxol: a novel investigational antimicrotubule agent." J. Natl. Cancer Inst. 82:1247-1259 (1990). 4. Parekh, H. and Simpkins, H. "The transport and binding of taxol." Gen. Pharmacol. 29:167-172 (1997). 5. Jordan, A., et al. "Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle investigational antimicrotubule agent." Med. Res. Rev. 18:259-296 (1998). 6. Wang, T.H., et al. "Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-termnial kinase (JNK)-dependent and -independent pathways in overian cancer cells." J. Biol. Chem. 274:8208-8216 (1999). 7. Shtil, A.A., et al. "Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells." Oncogene 18:377-384 (1999). 8. Srivastava, R.K., et al. "Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase." Mol. Cell. Biol. 18:3509-3517 (1998). 9. Torres, K., and Horwitz, S.B. "Mechanisms of Taxol-induced cell death are concentration dependent." Cancer Res. 58:3620-3626 (1998).
USBio References
1. Wong A., et al. 2018. Lipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment. Cell Death Discovery. Article number: 109. https://www.nature.com/articles/s41420-018-0127-5.pdf
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