Paraherquamide A CAS 77392-58-6

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P3106-80 Paraherquamide A (Antibiotic VM 29919) CAS: 77392-58-6

Specifications

References

CAS Number

77392-58-6

Grade

Highly Purified

Molecular Formula

C28H35N3O5

Molecular Weight

493.6

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Antibiotic VM 29919

Paraherquamide A was first reported as a mycotoxin related to the indole tremorgenic mycotoxins. Subsequent research identified a potent non-toxic paralysis of nematodes which led to the metabolite's development as a candidate anthelmintic. Paraherquamide A is a selective, competitive, cholinergic antagonist that distinguishes subtypes of cholinergic receptors.

Purity: > 95% by HPLC

Solubility: Soluble in ethanol, methanol, DMF or DMSO

Related to: Marcfortine A, Paraherquamide E

Source

Penicillium simplicissimum

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Paraherquamide and 2-deoxy-paraherquamide distinguish cholinergic receptor subtypes in Ascaris |muscle. Robertson A.P. et al. J. Pharmacol. Exp. Ther. 2002, 302, 853. |2. Novel antinematodal and antiparasitic agents from Penicillium charlesii I. Fermentation, isolation and |biological activity. Ondeyka J.G. J. Antibiot. 1990, 43, 1375. |3. The structure of parherquamide, a toxic metabolite from Penicillium paraherquei. Yamazaki M.E. et al. |Tetrahedron Lett. 1982, 22, 135.