PDZD11 (PDZ domain-containing protein 11; also AIPP1a and PISP) is a 17kD cytosolic protein that bears resemblance to members of the MALS/VELIS family of proteins. It is ubiquitously expressed, and appears to target calcium and copper ATPases to basolateral cell membranes. Human PDZD11 is 140aa in length. It contains but one PDZ domain (aa47-129) that apparently interacts with the C-terminus of partner proteins. One alternative start site exists that is 32aa upstream of the standard site. This generates the AIPP1b isoform. Full-length human PDZD11 shares 97% aa identity with mouse PDZD11.
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