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P4193-02 PINX1, 1-328aa, Recombinant, Human, His-Tag (67-11-3 Protein, Hepatocellular Carcinoma-related Putative Tumor Suppressor, LPTL, LPTS, PIN2 Interacting Protein 1) CAS:

Specifications
References
Grade
Purified
Accession Number
NP_060354
Molecular Weight
39.1
EU Commodity Code
30021019
Shipping Temp
Dry Ice
Storage Temp
-70°C

PINX1(PIN2-interacting protein 1) is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. This protein contains a TID (telomerase inhibiting domain) domain which is capable of binding MCRS1, TERT and TERF1. PINX1 has been shown to be a potent telomerase inhibitor and putative tumor suppressor.

Source
Recombinant human PINX1, fused to His-tag at N-terminus, was expressed in E.coli.
Molecular Weight: 39.1kD (348aa)
Sequence of amino acids
MGSSHHHHHH SSGLVPRGSH MSMLAERRRK QKWAVDPQNT AWSNDDSKFG QRMLEKMGWS KGKGLGAQEH GATDHIKVQV KNNHLGLGAT INNEDNWIAH QDDFNQLLAE LNTCHGQETT DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSK TDLDCIFGKR QSKKTPEGDA SPSTPEENET TTTSAFTIQE YFAKRMAALK NKPQVPVPGS DISETQVERK RGKKINKEAT GKDVESYLQP KAKRHTEGKP ERAEAQERVA KKKSAPAEEQ LRGPCWDQSS KASAQDAGDH VQPPEGRDFT LKPKKRRGKK KLQKPVEIAE DATLEETLVK KKKKKDSK
Endotoxin Level: ≤1EU/ug
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at 20 or 70°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Source
Recombinant, E. coli
Purity
≥95% (SDS-PAGE)
Concentration
~1mg/ml
Form
Supplied as liquid in 20 mM Tris-HCl, pH8.0, 1mM DTT, 10% glycerol.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Zhou XZ., et al. (2001). Cell. 107(3):347-59, 2. Yoo JE., et al. (2009). J Mol Biol. 388(5):928-40
USBio References
No references available
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