Pioglitazone Hydrochloride CAS 112529-15-4; freebase: 111025-46-8

CAS Number

112529-15-4; freebase: 111025-46-8

Grade

Highly Purified

Molecular Formula

C19H20N2O3S•HCl

Molecular Weight

392.9

EU Commodity Code

38220090

Shipping Temp

Storage Temp

-20°C

5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione Hydrochloride; 5-phenyl]methyl-2,4-thiazolidinedione; AD-4833; Actos; U-72107A

Used as an antidiabetic.

Synonyms

5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione Hydrochloride; 5-phenyl]methyl-2,4-thiazolidinedione; AD-4833; Actos; U-72107A

CAS No

112529-15-4; freebase: 111025-46-8

Molecular Formula

C19H20N2O3S•HCl

Molecular Weight

392.9

Appearance

White solid

Purity

≥98%

Melting Point

>187ºC (dec)

Solubility

DMSO (Slightly), Methanol (Slightly)

Method for Determining Identity

Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis

TLC Conditions

SiO2: Dichloromethane: Methanol: Ammonium Hydroxide; 9: 1: 0.1; Visualized with UV and KMnO4; Single spot, Rf=0.45

Chloride

~9%

Storage and Stability

May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

References

1. Hofmann, C., et al.: Endocrinology, 129, 1915(1991). 2. Kobayashi, M., et al.: Diabetes, 41, 476 (1992). 3. Kawaamori, R., et al.,: Diabetes Res. Clin. Pract., 41, 35 (1998).|Product-Specific Reference:|1. Yeligar SM, et al. 2017. Dysregulation of Alveolar Macrophage PPARγ, NADPH Oxidases, and TGFβ1 in Otherwise Healthy HIV-Infected Individuals. AIDS Res Hum Retroviruses. 33(10):1018-1026. doi: 10.1089/AID.2016.0030.

USBio References

1. Yeligar SM, et al. 2017. Dysregulation of Alveolar Macrophage PPARγ, NADPH Oxidases, and TGFβ1 in Otherwise Healthy HIV-Infected Individuals. AIDS Res Hum Retroviruses. 33(10):1018-1026. doi: 10.1089/AID.2016.0030.

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P4198-55 Pioglitazone Hydrochloride CAS: 112529-15-4; freebase: 111025-46-8

CAS Number

Grade

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione Hydrochloride; 5-phenyl]methyl-2,4-thiazolidinedione; AD-4833; Actos; U-72107A

References

USBio References

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