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P4262 Platencin CAS: 869898-86-2

Specifications
References
CAS Number
869898-86-2
Grade
Highly Purified
Molecular Formula
C24H27NO6
Molecular Weight
425.2
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Platencin is a more potent analogue of Platensimycin also discovered from a strain of Streptomyces platensis. Platencin shows potent in vivo efficacy without any observed toxicity. Platencin targets two essential proteins, β-ketoacyl-acyl carrier protein (ACP) synthase II (FabF) and III (FabH) whereas platensimycin targets only FabF.

Source
Platencin
Molecular Weight
~425.2
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Streptomyces sp. MST-AS5989
Purity
≥ 95% by HPLC
Form
Supplied as a light tan solid.
References
1. Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity. Jayasuriya, H., et al., Angew. Chem. Int. Ed. 46: 4684 (2007). 2. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Wang, J., et al., PNAS 104: 7612 (2007).
USBio References
No references available
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