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P9109-40N2 Goat Anti-PTPRN (Receptor-type Tyrosine-protein Phosphatase-like N, R-PTP-N, Islet Cell Antigen 512, ICA 512, Islet Cell Autoantigen 3, PTP IA-2, ICA3, ICA512)

Specifications
References
Clone Type
Polyclonal
Host
Goat
Source
Mouse
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu Mo Rt
Accession #
NP_002837.1
Gene ID
5798, 19275, 116660
Shipping Temp
Blue Ice
Storage Temp
-20°C

Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
ELISA: 1:16,000 Western Blot: 0.5-1.5ug/ml, observed in lysates of cell line NIH 3T3 on ~110kD bands Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to C-QGEGNIKKNRHPD, from mouse PTPRN, at the internal region of the protein (NP_002837.1).
Form
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes mouse PTPRN. Species sequence homology: Human and rat.
References
1. Buzzetti R, Di Pietro S, Giaccari A, Petrone A, Locatelli M, Suraci C, Capizzi M, Arpi ML, Bazzigaluppi E, Dotta F, Bosi E; Non Insulin Requiring Autoimmune Diabetes Study Group. High titer of autoantibodies to GAD identifies a specific phenotype of adult-onset autoimmune diabetes. Diabetes Care. 2007 Apr;30(4):932-8.
USBio References
No references available
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