Pentraxin 3 (PTX3), also known as TSG-14, belongs to the pentraxin family, which was named originally for the homopentameric structure formed by its members. PTX3/TSG-14 is a long pentraxin that contains a pentraxin-like domain at its carboxy-terminus with amino acid sequence similarity with short pentraxins (C-reactive protein and serum amyloid P component). PTX3 is a marker of the acute phase response and is highly expressed in advanced atherosclerotic plaques.
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