Rebeccamycin CAS 93908-02-2

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R1281-15 Rebeccamycin CAS: 93908-02-2

Specifications

References

CAS Number

93908-02-2

Grade

Highly Purified

Molecular Formula

C27H21Cl2N3O7

Molecular Weight

570.4

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

+4°C

Rebeccamycin is an indolocarbazole isolated from Lechevalieria aerocolonigenes. It displays a selective antitumour activity against several cell lines. Rebeccamycin's primary mechanism of action is via strong DNA intercalation resulting in the potent catalytic inhibition of both topoisomerases I and II. Analogues of rebecamycin are currently in several clinical trials for cancer therapy.

Purity: >99% by HPLC

Solubility: Soluble in THF or DMSO. Poorly soluble in methanol and water.

Related to: Staurosporine, Antibiotic UCN-01, Antibiotic UCN-02

Source

Lechevalieria sp.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Long |B.H. et al. Curr. Med. Chem. Anticancer Agents 2002, 2, 255. |2. Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the |indolocarbazole, rebeccamycin. Woo M.H. et al. J. Biol. Chem. 2002, 277, 3813. |3. Production and biological activity of rebeccamycin, a novel antitumor agent. Bush J.A. et al. J. Antibiot. |1987, 40, 668.