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S0647-10D Goat Anti-SEL1L (Sel-1 Suppressor of Lin-12-like, Suppressor of Lin-12-like Protein 1, SEL1-like, Sel-1L, SEL1L1, IBD2, PRO1063, Protein Sel-1 Homolog 1, TSA305, UNQ128)

Specifications
References
Clone Type
Polyclonal
Host
Goat
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Bo Ca Hu Mo Po Rt
Accession #
NP_005056.3
Gene ID
6400, 20338, 314352
Shipping Temp
Blue Ice
Storage Temp
-20°C

SEL1L may play a role in Notch signaling and be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
ELISA: 1:4000 Western Blot: 1-3ug/ml, observed in lysates of cell line HepG2 on ~80kD bands Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to C-TAYNSYKDGDYN, from human SEL1L, at the internal region of the protein (NP_005056.3).
Form
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human SEL1L. Species sequence homology: Bovine, canine, mouse, porcine and rat.
References
1. Schelhaas M, Malmström J, Pelkmans L, Haugstetter J, Ellgaard L, Grünewald K, Helenius A. Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells. Cell. 2007 Nov 2;131(3):516-29.
USBio References
No references available
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