Synuclein, alpha, beta, gamma

Clone Type

Polyclonal

Host

Rabbit

Source

Human

Isotype

IgG

Grade

Affinity Purified

Applications

E WB

Crossreactivity

Shipping Temp

Blue Ice

Storage Temp

-20°C

The synucleins (alpha, beta and gamma) are a family of soluble presynaptic proteins expressed in neural tissue. Synucleins are thought to be involved in neuronal plasticity, synaptic function, and neurodegenerative diseases. Gamma-synuclein is abnormally expressed in tumor tissues of different cancers.

Applications

Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilutions

Optimal dilutions to be determined by the researcher.

Storage and Stability

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunogen

Synthetic peptide corresponding to aa11-26, AKEGVVAAEKTKQGV of human alpha, beta and gamma-synuclein

Form

Supplied as a liquid in PBS, pH 7.2.

Purity

Purified by Protein G affinity chromatography.

Specificity

Recognizes human Alpha, Beta and Gamma- Synuclein.

References

Clayton, D.F. & George, J.M. (1998) Trends Neurosci. 21(6), 249 254. Lavedan, C. (1998) Genome Res. 8,871 - 880. George, J.M.(2002) Genome Biol.3,3002.1 - 3002.6