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T2400-15A Mouse Anti-TRF2 (Telomeric Repeat-binding Factor 2, TTAGGG Repeat-binding Factor 2, Telomeric DNA-binding Protein, TERF2, TRBF2)

Specifications
References
Clone Type
Monoclonal
Host
Mouse
Source
Human
Swiss Prot
Q15554
Isotype
IgG1,k
Clone Number
11E354 (4A794.15)
Grade
Affinity Purified
Applications
ChIP E FC IC IF IHC IP WB
Crossreactivity
Hu Mo Rt
Accession #
NP_005643
Shipping Temp
Blue Ice
Storage Temp
-20°C

TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length (1). TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes (1). TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini (2). The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells (2). Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types (3).

Applications
Suitable for use in Western Blot, ChIP, ELISA, Flow Cytometry, Immunofluorescence/Immunocytochemistry, Immunohistochemistry and Immunoprecipitation. Other applications not tested.
Recommended Dilution
ELISA: 2ug/ml Flow Cytometry: 0.1ug/10e6 cells Immunohistochemistry (frozen): 5ug/ml Immunoprecipitation: 2ug/10e6 cells Western Blot: 2-4ug/ml Immunofluorescence (IC): 1:10-1:500 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Full-length recombinant protein corresponding to TRF2 protein.
Form
Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Purity
Purified by Protein G affinity chromatography.
Specificity
Recognizes human TRF2. Species Crossreactivity: mouse, Muntjac (deer), rat.
References
1. Broccoli, D., et al. Nature Genetics 17:231-239 (1997). 2. Van Steensel, B., et al. Cell 92:401-413 (1998). 3. Karlseder, J., et al. Science 283: 1321-1325 (1999).
USBio References
No references available
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