Tetraspanin-8 (TSPAN8), is a member of the transmembrane 4 superfamily. It is a cell surface 27-34kD protein with 4 transmembrane segments, and a large extracellular loop (LEL) domain from aa106-206. Both the N- and C-termini are intracellular. The protein is involved in cell motility, metastasis, cell proliferation and differentiation, and is over-expressed in different carcinomas, including hepatocellular carcinoma and colon cancer. Human Tetraspanin-8 shares 70aa sequence identity with both mouse and rat TSPAN8.
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