TORC2, also known as CREB regulated transcription coactivator 1 (crtc2), is a 7080kD protein that functions as a coactivator for CREB1 in promoting transcription through both consensus and variant cAMP response element (CRE) sites. TORC2 activity is important in regulating the expression of genes involved in cellular energy metabolism. Its Oglycosylation triggers TORC2 dependent induction of hepatic gluconeogenic enzymes. It mediates hypothalamic glucose sensing and also the sensing of endoplasmic reticulum stress. In addition, TORC2 contributes to the transcription of HTLV 1 genes and the activation of latent EBV infections. Within aa454-612 mouse TORC2 shares 84% and 98% aa sequence identity with human and rat TORC2, respectively.