Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
Applications
Suitable for use in Immunohistochemistry, ELISA and Immunofluorescence. Other applications not tested.
Recommended Dilutions
Immunohistochemistry (FFPE): 3.75ug/ml Requires HIER citrate buffer, pH 6.0 ELISA (Peptide): 1:32,000 Immunofluorescence: 10ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to aa722-733, C-NLKQKRDENYQK, in the internal region of human TRPC1.
Form
Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human TRPC1. Species Crossreactivity: monkey, mouse, rat, canine, bovine, equine, rabbit, porcine and chicken
TDS
NCBI
UniProt
Tech Support
Customer Service
