Tumor Necrosis Factor alpha (TNF-a) is a potent immunomodulator and proinflammatory cytokine. The secreted form of TNF-a is 17kD while the membrane form (mTNF-a) has a molecular weight of 26kD. Secreted TNF-a appears to be generated from the precursor mTNF-a. 1 Membrane TNF-a has been described on the surface of monocytes and activated T lymphocytes.This anti-TNF-a monoclonal antibody recognizes mTNF-a transfected into a cell line, and is designed for use as a flow cytometry reagent.
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