VANGL2 (van Gogh-like protein 2; also Strabismus and Ltap) is a 65kD member of the Vang family of proteins. It is found in the membranes of embryonic neurons and epithelium where it associates with DVL1-3 and various frizzleds. VANGL2 mutations are associated with neural tube defects. Human VANGL2 is a 521 amino acid (aa) 4-transmembrane protein that contains an N-terminal (aa 1-108) and C-terminal (aa 239-521) cytoplasmic domain. There is a Ser-rich region in the N-terminus (aa 5-20) and a PDZ-binding motif over aa 506-521. Over aa 241-521, human, mouse and rat show total identity in amino acid sequence.