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W1018-50M Mouse Anti-West Nile Virus

Specifications
Clone Type
Monoclonal
Host
Mouse
Isotype
IgG1
Clone Number
10D34
Grade
Affinity Purified
Applications
E IF
Shipping Temp
Blue Ice
Storage Temp
-20°C

West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state (reviewed in. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins which play a major role for WNV entry into target cells. The viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway as delivery of core gene delivery into the striatum of mouse brain and skeletal muscle resulted in cell death and inflammation.

Applications
Suitable for use in Immunofluorescence and ELISA. Other applications not tested.
Recommended Dilution
Immunofluorescence: 1:10-1:50 ELISA: 1:20-1:200 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
West Nile Virus
Form
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. No Stabilizing proteins added.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes the envelope protein. Has positive reactivity with WNV and SLE flaviviruses. Has a negative reaction with JEV, YFV, DEN, TBE, EEE, WEE, POW, LAC, VEE.
Conjugates
Pricing
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