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X1048-11B Mouse Anti-XPG (Xeroderma pigmentosum Type G, ERCC5, ERCM2, Excision Repair Cross Complementing Rodent Repair Deficiency, UVDR, Xeroderma Pigmentosum Complementation Group G, XPGC)

Specifications
Clone Type
Monoclonal
Host
Mouse
Source
Human
Isotype
IgG1
Clone Number
2328C1a
Grade
Affinity Purified
Applications
DB WB
Crossreactivity
Hu
Accession #
NM_000123
Shipping Temp
Blue Ice
Storage Temp
-20°C

Xeroderma pigmentosum (XP) is characterized high sensitivity to UV light and high incidence of skin cancer. XP fall into seven complementation groups, XPA to XPG. They are lacking a functional helicase, endonuclease, or lesion-recognizing proteins involved base excision repair. Xeroderma pigmentosum type G (XPG) is one of the rarest and phenotypically heterogeneous forms of genetic disorder. XPG gene encodes an acidic protein with an estimated MW ~133kD that confers normal UV-resistance. XPG is a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family responsible to UV-induced DNA repair. Human XPG makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29aa region of human XPG (981-1009aa) contains the PCNA binding activity. A conserved Arg in XPG (Arg992) is crucial for its PCNA-binding activity. Replication protein A (RPA) binds specifically and directly to two excision repair proteins, Xeroderma pigmentosum damage recognition protein XPA and the endonuclease XPG.

Applications
Suitable for use in Dot Blot and Western Blot. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Partial recombinant protein corresponding to human ERCC5
Form
Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
Purity
Purified by Protein G affinity chromatography from hybridoma culture supernatant
Specificity
Recognizes human ERCC5.
Conjugates
Pricing
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