Zinc finger protein ZIC2 is a member of the GLI C2H2-type zinc-finger protein family. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Gene mutations cause holoprosencephaly type 5 in human brain and neural tube defects. Recent studies show that complete deficiency of the related murine ZIC2 transcription factor can also be a contributing factor to variable midline deficiencies, presenting during mid-gastrulation and similar forebrain anomalies.
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