Testis expressed sequence 11 (Tex11), also known as ZIP4 homolog, is a 947 aa X chromosome-encoded protein that is selectively expressed in primordial male germ cells. It associates with Nbs1 of the Mre11 protein complex which results in localization to areas of synaptonemal contact between meiotic chromosomes. During meiosis, ZIP4H/Tex11 promotes sister chromatid synapsis and crossover in response to programmed double stranded DNA breaks. ZIP4H/Tex11 deficiency leads to increased spermatocyte apoptosis and male sterility. Alternate splicing in mouse generates an additional isoform with a substitution (aa691-707) and truncation (aa708-947) at the C-terminus. Within aa768-947, mouse ZIP4H/Tex11 shares 44% and 73% aa sequence identity with human and rat ZIP4H/Tex11, respectively.
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