Atorvastatin impurity. An oxidative degradation product of Atorvastatin.
Melting Point
179-182°C
Solubility
Chloroform
Method for Determining Identity
Proton NMR (CDCl3), 19F NMR (CDCl3), and MS
TLC Conditions
SiO2; Hexane: Ethyl Acetate (3:2); Visualized with UV and AMCS. Single spot (Rf= 0.7).
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Source
Synthetic
Purity
≥ 90%
Form
White solid
References
Roth, B., et al.: J. Med. Chem., 34, 357 (1991), Lea, A., et al.: Drugs, 53, 828 (1997), Black, A., et al.: Drug Metab. Dispos., 27, 916 (1999),