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007084 CP-100356 Hydrochloride CAS: 142715-48-8

Specifications
References
CAS Number
142715-48-8
Grade
Highly Purified
Molecular Formula
C31H37ClN4O6
Molecular Weight
597.1
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine Monohydrochloride;

CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC50 >15 mM).

Form
Off-White to Light Tan Solid
Melting Point
210-212°C
Solubility
Chloroform, Methanol
Pfizer Compound
References
Ayrton, A., et al.: Xenobiotica, 31, 469 (2001), Mizuno, N., et al.: Pharmacol. Rev., 55, 425 (2003), Fojo, T., et al.: Clin. Breast Cancer, 7, 749 (2007), Polli, J., et al.: Drug Metab. Dispos., 36, 695 92008),
USBio References
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