4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethyl-benzeneacetonitrile; 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile; BEZ 235;
Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR.
Melting Point
As Reported
Solubility
As Reported
Method for Determining Identity
Proton NMR (DMSO-d6) and Mass Spectrometry
TLC Conditions
As Reported
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Store under inert atmosphere.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Source
Synthetic
Purity
~90%
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Konstantinidou, G., et al., Cancer Res. 69: 7644 (2009). 2. Frederick, R., et al., Bioorg. Med. Chem. Lett. 19: 5842 (2009). 3. Pollizzi, K., et al., Mol. Cancer 8: 38 (2009).