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022761 Vemurafenib, Free Base (PLX4032) CAS: 918504-65-1

Specifications
References
CAS Number
918504-65-1
Grade
Highly Purified
Molecular Formula
C23H18ClF2N3O3S
Molecular Weight
489.92
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide; PLX4032; RG7204; RO51-85426; Zelboraf

Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600.

Appearance
Cyrstalline solid
Purity
≥99% (HPLC) ≥99% (TLC)
Melting Point
269-270.5°C
Method for Determining Identity
Proton NMR (CD3OD and DMSO-d6), 19F NMR (CD3OD) Spectroscopic and Mass Spectrometric Analysis
Solubility
Soluble in DMSO at 100mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 25-50uM; buffers, serum, or other additives may increase or decrease the aqueous solubility
Storage
Store at or below -20ºC.
Note
As of September 2011 the current correct CAS number for vemurafenib, also known as PLX4032, is given above. Chemical Abstracts Service recently canceled another CAS number, 1029872-54-5, that had previously been used for vemurafenib under its older name, PLX4032. However, this canceled number remains in wide use and receives the vast majority of hits on Google.
Source
Synthetic
Purity
≥99% (HPLC), ≥99% (TLC)
Form
Cyrstalline solid
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Halaban, R. et al.: Pigm. Cell. Melonoma Res., 23, 190 (2010); 2. Yang, H. et al.: Cancer Res., 70, 5518 (2010); 3. Comin-Anduix, B. et al.: Clin. Cancer Res., 16, 6040 (2010);
USBio References
No references available
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