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022790 Vildagliptin CAS: 274901-16-5

Specifications
References
CAS Number
274901-16-5
Grade
Highly Purified
Molecular Formula
C₁₇H₂₅N₃O₂
Molecular Weight
303.4
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
(2S)-1-[2-[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2-pyrrolidinecarbonitrile; LAF 237; NVP-LAF 237; Galvus

Glyptins are class of oral anti-hyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase. Aside from their use in type 2 diabetes, gliptins have positive cardiovascular and anti-inflammtatory effects. Antidiabetic.

Synonyms
(2S)-1-[2-[(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2-pyrrolidinecarbonitrile; LAF 237; NVP-LAF 237; Galvus
CAS No
274901-16-5
Molecular Formula
C₁₇H₂₅N₃O₂
Molecular Weight
303.4
Appearance
White to off-white solid
Purity
≥97%
Melting Point
>145°C (dec.)
Solubility
DMSO (Slightly), Methanol (Slightly)
Storage and Stability
May be stored at RT for short-term only. Hygroscopic. Under inert atmosphere. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004), Ahren, B., et al.: Diabetes Care, 27, 2874 (2004), Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004)
USBio References
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