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022910 XAV 939 CAS: 284028-89-3

Specifications
References
CAS Number
284028-89-3
Grade
Highly Purified
Molecular Formula
C14H11F3N2OS
Molecular Weight
312.31
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
RT
1,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one; NVP-XAV 939;

A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.

References
Huang, S. et al.: Nature, 461, 614 (2009); Wang, H. et al.: ACS Chem. Biol., 6, 192 (2011); Adles, M.E. et al.: Sci. Signal., 91, ec326 (2009);
USBio References
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