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044678 Compound 34 CAS: 564462-36-8

Specifications
References
CAS Number
564462-36-8
Grade
Highly Purified
MDL Number
MFCD08702692
Molecular Formula
C31H24F3N3O3
Molecular Weight
543.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C/-20°C
(2S,3R)-3-(3,4-Difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-2-oxo-5-phenyl-2,3-1H-benzodiazepin-3-yl)butyramide

Cell permeable, highly potent inhibitor of gamma-secretase (IC50 = 0.06nM).

Synonyms
(2S,3R)-3-(3,4-Difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-2-oxo-5-phenyl-2,3-1H-benzo[e][1,4]diazepin-3-yl)butyramide
CAS No
564462-36-8
Molecular Formula
C31H24F3N3O3
Molecular Weight
543.5
Solubility
DMSO
Appearance
Supplied as a white to off-white powder.
Purity
≥98% (NMR)
Storage and Stability
Store at 4°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement: I. Churcher, et al.; J. Med. Chem 46 2275 (2003).
USBio References
No references available
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