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044998 Latrunculin B CAS: 76343-94-7

Specifications
References
CAS Number
76343-94-7
Grade
Highly Purified
MDL Number
MFCD00270879
Molecular Formula
C₂₀H₂₉NO₅S
Molecular Weight
395.5
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
LAT-B, NSC 339663

Latrunculin B is a cell-permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin.

Source
Latrunculia magnifica
Synonyms
LAT-B; NSC 339663
CAS No
76343-94-7
Molecular Formula
C₂₀H₂₉NO₅S
Molecular Weight
395.51
Appearance
Supplied as a white to light yellow solid.
Purity
≥98% (HPLC)
Solubility
DMSO, EtOH
Storage and Stability
Store at -20°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells: I. Spector, et al.; Science 219:493 (1983), |2. Latrunculin inhibits the microfilament-mediated processes during fertilization, cleavage and early development in sea urchins and mice: G. Schatten, et al.; Exp. Cell Res. 166:191 (1986), 3. Inhibition of actin polymerization by latrunculin: A: M. Coue, et al.; FEBS Lett. 213:316 (1987), 4. Latrunculins-novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D: I. Spector, et al.; Cell Motil. Cytoskeleton 13:127 (1989), 5. Effects of cytochalasin D and latrunculin B on mechanical properties of cells: T. Wakatsuki, et al.; J. Cell. Sci. 114:1025 (2001)
USBio References
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