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136754 Apicidin, HDAC Inhibitor (Cyclo- N-O-methyl-L-tryptophanyl-Lisoleucinyl- Dpipecolinyl- L-2-amino-8-oxodecanoyl) CAS: 183506-66-3

Specifications
References
CAS Number
183506-66-3
Grade
Highly Purified
Molecular Formula
C34H49N5O6
Molecular Weight
623.8
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
Cyclo- N-O-methyl-L-tryptophanyl-Lisoleucinyl- Dpipecolinyl- L-2-amino-8-oxodecanoyl

Cyclopeptide inhibitor of histone deactylases (HDACs). Inhibits HeLa cell proliferation (IC50=50- 100nM) and induces reversible transcriptional activation of p21 (WAF1). Decreases HIF1alpha protein levels and transcriptional activity in human and mouse tumor cell lines. Cell permeable.

Solubility
DMSO (~10mg/ml)
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Synthetic
Purity
~98% (TLC)
Concentration
Not determined
Form
Supplied as a lyophilized powder in PBS. Reconstitute with sterile dH20.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Darkin-Rattray S.J., et al. (1996) Proc. Natl. Acad. Sci. USA. 93: 13143. 2. Han J.W., et al. (2000) Cancer Res. 60: 6068. 3. Kim S.H., et al. (2007) Oncol. Rep. 17: 647.
USBio References
No references available
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