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162989 CAL-101 CAS: 870281-82-6

Specifications
References
CAS Number
870281-82-6
Grade
Highly Purified
Molecular Formula
C₂₂H₁₈FN₇O
Molecular Weight
415.42
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
RT/4°C
5-Fluoro-3-phenyl-2-[(1S)-1-(1H-purin-6-ylamino)propyl]-4(3H)-quinazolinone; CAL 101; Delalisib; GS 1101; Idelalisib; N6-[(S)-1-(5-Fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]adenine; Zydelig

CAL-101 is a PI3K/mTOR pathway inhibitor used in the treatment of myeloid leukemia through sensitizing the cells to combatting drugs. Potent PI3K-p110-delta inhibitor.

Synonyms
5-Fluoro-3-phenyl-2-[(1S)-1-(1H-purin-6-ylamino)propyl]-4(3H)-quinazolinone; CAL 101; Delalisib; GS 1101; Idelalisib; N6-[(S)-1-(5-Fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]adenine; Zydelig
CAS No
870281-82-6
Molecular Formula
C₂₂H₁₈FN₇O
Molecular Weight
415.42
Solubility
DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Very Slightly, Heated)
Melting Point
250-252ºC
Appearance
Supplied as a pale brown solid.
Storage and Stability
Store at 4°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
Airiau, K. et al.: Cell. Death. Dis., 4, e827 (2013); Kulesz-Martin, M. et al Canc. Biol. Ther., 14m 95 (2013);
USBio References
No references available
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