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167088 YIL 781, Hydrochloride Salt CAS: 875258-85-8

Specifications
References
CAS Number
875258-85-8
Grade
Highly Purified
Molecular Formula
C₂₄H₂₈FN₃O₂.HCl
Molecular Weight
445.96
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone

Ghrelin receptor antagonist (GHS-R1a) (Ki = 17nM). Displays no significant affinity for the motilin receptor (Ki = 6uM). Blocks the effects of ghrelin on insulin secretion both in vivo and in vitro. Improves glucose homeostasis in vivo.

Purity
≥98%
Solubility
Soluble to 100mM in DMSO and to 100mM in water
Storage
Desiccate at RT
Alternate Name
6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone
CAS Number
875258-85-8
Molecular Formula
C₂₄H₂₈FN₃O₂.HCl
Molecular Weight
445.96
Storage
-20°C
References
1. Perdona, E. et al.: Eur. J. Pharmacol., 650, 178 (2011).|2. Rudolph, J. et al.: J. Med. Chem., 50, 5202 (2007).|3. D Lin et al:. Endocrinology, 155(7), 2355-2362 (2014).
USBio References
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