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207056 Ansatrienin A (Mycotrienin I, Antibiotic T 23I) CAS: 82189-03-5

Specifications
References
CAS Number
82189-03-5
Grade
Highly Purified
Molecular Formula
C36H48N2O8
Molecular Weight
636.8
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Antibiotic. Antitumor compound. Antifungal. Inhibits osteoclastic bone resorption.

CAS Number
82189-03-5
Source
Streptomyces collinus
Formula
C36H48N2O8
Solubility
100% ethanol, methanol, dimethyl formamide or DMSO
Molecular Weight
~636.8
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Streptomyces collinus
Purity
≥98% (HPLC)
Form
Supplied as a yellow powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Mycotrienin, a new polyene antibiotic isolated from Streptomyces: C. Coronelli, et al.; J. Antibiot. (Tokyo) 20: 329 (1967). 2. Die Konstitution der fungistatischen Ansamycin-Antibiotica Ansatrienin A und B: M. Damberg, et al.; Tetra- hedron Lett. 23: 59 (1982). 3. Studies on mycotrienin antibiotics, a novel class of ansamycins. I. Taxonomy, fermentation, isolation and properties of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35: 1460 (1982). 4. Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35: 1467 (1982). 5. Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis- diamminedichloroplatinum and 5-fluorouracil by mycotrienins and mycotrienols: M. Kuwano, et al.; Gann. 74: 759 (1983). 6. Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption: D. Feuerbach, et al.; J. Biol. Chem. 270: 25949 (1995). 7. (+)-trienomycin A, B, C, and F and (+)- mycotrienins I and II: relative and absolute stereochemistry: A. B. Smith, et al.; JACS 118: 8308 (1996). 8. Total syntheses of (+)-trienomycins A and F via a unified strategy: A. B. Smith, et al.; JACS 118: 8316 (1996). 9. Total synthesis of (+) -mycotrienol and (+) -mycotrienin I: application of asymmetric crotylsilane bond constructions: C. E. Masse, et al.; JACS 120: 4123-4134 (1998)
USBio References
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