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207061 Aranciamycin CAS: 72389-06-1

Specifications
References
CAS Number
72389-06-1
Grade
Highly Purified
Molecular Formula
C27H28O12
Molecular Weight
544.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Antibiotic. Similar to steffimycin. Active against Gram-positive bacteria. Clostridium histolyticum collagenase inhibitor. Antitumor compound.

CAS Number
72389-06-1
Source
Streptomyces echinatus
Formula
C27H28O12
Method for Determining Identity
Proton NMR
Solubility
DMSO
Molecular Weight
~544.5
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Streptomyces echinatus
Purity
≥98% (HPLC)
Form
Supplied as a yellow to orange solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Aranciamycin: W. Keller-Schierlein, et al.; Helv. Chim. Acta 53: 779 (1970). 2. Inhibition of collagenase by aranciamycin and aranciamycin derivatives: M. Bols, et al.; J. Med. Chem. 35: 2768 (1992). 3. Structure of the anthracycline antibiotic aranciamycin: K. Schmidt-Bäse, et al.; Acta Cryst. C 49: 250 (1993) 4. Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase: A. Luzhetskyy, et al.; ChemBioChem 8: 599 (2007) 5. Aranciamycin analogs generated by combinatorial biosynthesis show improved antitumor activity: A. Luzhet skyy, et al.; Appl. Microbiol. Biotechnol. 80: 15 (2008). 6. Aranciamycin anhydride, a new anthracycline-type antibiotic isolated from Streptomyces sp. Tü 6384: J. Nachtigall, et al.; J. Antibiot. 63: 397 (2010)
USBio References
No references available
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