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207089 Rubromycin Beta (Methyl-8,10'-dihydroxy-5,7-dimethoxy-4,9,9'-trioxo-4,4',9,9'-tetrahydro-3H,3'H-spiro[naphtho[2,3-b]furan-2,2'-pyrano[4,3-g]chromene]-7'-carboxylate) CAS: 27267-70-5

Specifications
References
CAS Number
27267-70-5
Grade
Highly Purified
MDL Number
MFCD03095570
Molecular Formula
C27H20O12
Molecular Weight
536.4
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Antibiotic. HIV-1 reverse transcriptase inhibitor. Human telomerase inhibitor. Cytostatic against different tumor cell lines.

Synonyms
Methyl-8,10'-dihydroxy-5,7-dimethoxy-4,9,9'-trioxo-4,4',9,9'-tetrahydro-3H,3'H-spiro[naphtho[2,3-b]furan-2,2'-pyrano[4,3-g]chromene]-7'-carboxylate
Source
Streptomyces sp.
CAS Number
27267-70-5
Molecular Formula
C27H20O12
Molecular Weight
536.4
Purity (HPLC)
≥98%
Appearance
Dark blue solid
Solubility
Chloroform
Storage and Stability
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. The structure of rubromycin: H. Brockmann, et al.; THL 30: 3525 (1966). 2. Rubromycin II: H. Brockmann, et al.; Chem. Ber. 102: 126 (1969). 3. Rubromycins. 3. The constitution of alpha-rubromycin, beta-rubromycin, gamma-rubromycin, and gamma- iso-rubromycin: H. Brockmann & A. Zeeck; Chem. Ber. 103: 1709 (1970). 4. Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site: M.E. Goldman, et al.; Mol. Pharmacol. 38: 20 (1990). 5. Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety: T. Ueno, et al.; Biochemistry 39: 5995 (2000). 6. Structural and biosynthetic investigations of the rubromycins: C. Puder, et al.; Eur. J. Org. Chem. 2000: 729 (2000). 7. Rubromycins: Structurally intriguing, biologically valuable, synthetically challenging antitumour antibiotics: M. Brasholz, et al.; Eur. J. Org. Chem. 2007: 3801 (2007)
USBio References
No references available
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