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207124 CJ-21058 ((5R,Z)-3-(Hydroxy((1R,2S,6S,8aS)-1,3,6-trimethyl-2-((E)-prop-1-en-1-yl)-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl)methylene)-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione) CAS: 405072-57-3

Specifications
References
CAS Number
405072-57-3
Grade
Highly Purified
Molecular Formula
C23H33NO4
Molecular Weight
387.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Antibiotic. SecA inhibitor. Antibacterial and antifungal. Cytotoxic. Methyl analog of equisetin.

Source
Phoma sp.
Formula
C23H33NO4
Solubility
Methylene chloride, DMSO or methanol
Molecular Weight
~387.5
Method for Determining Identity
Proton NMR
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Phoma sp.
Purity
≥98% (HPLC)
Form
Supplied as an off-white solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. CJ-21,058, a new SecA inhibitor isolated from a fungus Y. Sugie, et al. J. Antibiot. 55: 25 (2002). 2. Discovery of the first SecA inhibitors using structure-based virtual screening M. Li, et al. BBRC 386 839 (2008). 3. Post-translational import of protein into the endoplasmic reticulum of atrypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities B. Patham, et al. Biochem. J. 419: 507 (2009)
USBio References
No references available
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