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207197 Rubromycin Gamma CAS: 27267-71-6

Specifications
References
CAS Number
27267-71-6
Grade
Highly Purified
Molecular Formula
C26H18O12
Molecular Weight
522.4
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Antibiotic. HIV-1 reverse transcriptase and human telomerase inhibitor. Antibacterial. Cytostatically active against different tumor cell lines.

CAS Number
27267-71-6
Source
Streptomyces sp.
Formula
C26H18O12
Purity
≥98% (HPLC)
Form
Supplied as a red powder.
Solubility
Methylene chloride, DMSO or methanol
Molecular Weight
522.4
Storage and Stability
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. Rubromycins. 3. The constitution of alpha-rubromycin, beta-rubromycin, gamma-rubromycin, and gamma- iso-rubromycin: H. Brockmann & A. Zeeck; Chem. Ber. 103: 170 (1970). 2. Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive in- teraction at the template.primer site: M.E. Goldman, et al.; Mol. Pharmacol. 38: 20 (1990). 3. Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety: T. Ueno, et al.; Biochemistry 39: 5995 (2000). 4. Rubromycins: Structurally intriguing, biologically valuable, synthetically challenging antitumour antibiotics: M. Brasholz, et al.; Eur. J. Org. Chem. 3801 (2007) 5. Total synthesis of (+/-)-gamma-rubromycin on the basis of two aromatic Pummerer-type reactions: S. Akai, et al.; Angew. Chem. Int. Ed. 46: 7458 (2007). 6. An efficient formal synthesis of the human telomerase inhibitor (+/-)- gamma-rubromycin: D.C. Rathwell, et al.; Angew. Chem. Int. Ed. 48: 7996 (2009)
USBio References
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