Rubratoxin A CAS 22467-31-8

CAS Number

22467-31-8

Grade

Highly Purified

Molecular Formula

C₂₆H₃₂O₁₁

Molecular Weight

520.2

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

BRN 1633008; HSDB 3532, (4S,5R,10R)-rel-10-[(R)-[(2R)-3,6-dihydro-6-oxo-2H-pyran-2-yl]hydroxymethyl]-4,5,8,9,10,11-hexahydro-4,8-dihydroxy-5-[(1S)-1-hydroxyheptyl]-1H-cyclonona[1,2-c:5,6-c']difuran-1,3,6-trione

Mycotoxin. Potent and selective competitive protein phosphatase 2A (PP2A) inhibitor. Does not inhibit PP1, PP2B, PTP1B, ALP and CIP. Antitumor agent. Antimetastatic.

CAS Number

22467-31-8

Alternate Names

BRN 1633008; HSDB 3532, (4S,5R,10R)-rel-10-[(R)-[(2R)-3,6-dihydro-6-oxo-2H-pyran-2-yl]hydroxymethyl]-4,5,8,9,10,11-hexahydro-4,8-dihydroxy-5-[(1S)-1-hydroxyheptyl]-1H-cyclonona[1,2-c:5,6-c']difuran-1,3,6-trione

Source

Penicillium sp.

Molecular Formula

C₂₆H₃₂O₁₁

Solubility

Methanol, ethanol, acetone or DMSO

Molecular Weight

520.2

Purity

≥95% (HPLC)

Appearance

Supplied as a white powder.

Storage and Stability

May be stored at 4°C for short-term only. Long-term storage is recommended at -20°C. Stable for 1 year after receipt. Protect from light when in solution. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

References

1. The structure of rubratoxin A, a toxic metabolite of Penicillium rebrum: M.O. Moss, et al.; Tetrahedron Lett. 5: 367 (1969). 2. Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis: S. Wada, et al.; Cancer Sci. 101: 743 (2010).

USBio References

No references available

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207390 Rubratoxin A CAS: 22467-31-8

CAS Number

Grade

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

BRN 1633008; HSDB 3532, (4S,5R,10R)-rel-10-[(R)-[(2R)-3,6-dihydro-6-oxo-2H-pyran-2-yl]hydroxymethyl]-4,5,8,9,10,11-hexahydro-4,8-dihydroxy-5-[(1S)-1-hydroxyheptyl]-1H-cyclonona[1,2-c:5,6-c']difuran-1,3,6-trione

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