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207396 Sarcophine (NSC250434) CAS: 55038-27-2

Specifications
References
CAS Number
55038-27-2
Grade
Highly Purified
MDL Number
MFCD01709460
Molecular Formula
C20H28O3
Molecular Weight
316.4
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Acetylcholine esterase and ATPase inhibitor. Ichthyotoxin. Tumorigenesis and JB6 cell trans- formation inhibitor.

Alternate Name
NSC250434
CAS Number
55038-27-2
Source
Sarcophyton glaucum (soft coral)
Formula
C20H28O3
Solubility
Methanol or dichloromethane
Purity
≥97% (HPLC)
Form
Supplied as a white to off-white solid.
Molecular Weight
316.4
Storage and Stability
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. Sarcophine, a new epoxy cembranolide from marine origin: J. Bernstein, et al.; Tetrahedron 30: 2817 (1974). 2. Sarcophine - a new toxin from the soft coral Sarcophyton glaucum (Alcyonaria): I. Neeman, et al.; Toxicon 12: 593 (1974) 3. Inhibition of phosphofructokinase by the toxic cembranolide sarcophine isolated from the soft-bodied coral Sarcophyton glaucum: A. Erman & I. Neéman; Toxicon 15: 207 (1977). 4. Structurally novel boconversion products of the marine natural product sarcophine effectively inhibit JB6 cell transformation: K.A. El Sayed, et al.; J. Org. Chem. 63: 7449 (1998) 5. S.S. Sawant, et al.; J. Nat. Prod. 69: 1010 (2006). 6. Cembranoid diterpenes and a briarane diterpene from corals: D. Grote, et al.; Nat. Prod. Res. 20: 285 (2006). 7. Anti-proliferative potential of sarcophine and its semi-synthetic sulfur-containing derivatives against human mammary carcinoma cell lines: J.M. Arif, et al.; J. Nat. Med. 61: 154 (2007) 8. HPLC method for the quantitative determination of sarcophine, a source of cembranoids with cancer chemo- preventive activity: S.S. Bilasy, et al.; J. Pharm. Biomed. Anal. 46: 784 (2008). 9. New cembranoid diterpenes from the Vietnamese soft coral Sarcophyton mililatensis stimulate osteoblastic differentiation in MC3T3-E1 cells: N.X. Cuong, et al.; Chem. Pharm. Bull. (Tokyo) 56: 988 (2008). 10. Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors: H.M. Hassan, et al.; Bioorg. Med Chem. 19: 625 (2011). 11. Chemopreventive effect of sarcophine-diol on NOR-1-induced TPA-promoted skin carcinogenesis in female HOS: HR-1 mice: P.T. Szymanski, et al.; Nat. Prod. Commun. 8: 153 (2013)
USBio References
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