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217133 9-Phenanthrol, TRPM4 Inhibitor (Phenanthren-9-ol, 9-Hydroxyphenanthrene) CAS: 484-17-3

Specifications
References
CAS Number
484-17-3
Grade
Highly Purified
Molecular Formula
C₁₄H₁₀O
Molecular Weight
194.2
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

A cell permeable hydroxytricyclic derivative that acts as a specific and reversible inhibitor of transient receptor potential melastatin 4 (TRPM4) (IC50=20uM in HEK293 cells). Does not affect TRPM5 and cystic fibrosis transmembrane conductance regulators (CFTR) channels. Decreases the occurrence of early after depolarizations (EAD) and exhibits an anti-arrhythmic effect that is independent of the action of protein kinase A. Shown to abolish nMDA-induced burst firing in dopaminergic neurons. Does not affect K+ currents at ~10uM, but at higher concentration (~100uM) it reversibly reduces K+ currents.

CAS Number
484-17-3
Formula
C₁₄H₁₀O
Molecular Weight
194.2
Solubility
DMSO (50mg/ml)
Purity
≥95% (HPLC)
Appearance
Supplied as a brown solid.
Storage and Stability
Store at -20°C under inert atmosphere. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards:  All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Grand, T., et al. 2008. Brit. Journ. Pharm.153, 1697.|2. Simard, C., 2012. Brit. Journ. Pharm.165, 2354.
USBio References
No references available
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