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217289 CRM1 Inhibitor III (Chromosome Region Maintenance 1 Protein Inhibitor III, (Z)-But-2-enedioic acid (4’-bromophenyl)amide (3’’-chlorophenyl)amide, Exportin 1 Inhibitor III, XPO1 Inhibitor III) CAS:

Specifications
References
Grade
Highly Purified
Molecular Formula
C₁₆H₁₂BrClN₂O₂
Molecular Weight
379.6
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C

A cell-permeable butenediamide compound that acts as a potent, active site cysteine reactive irreversible inhibitor of CRM1/exportin 1. Shown to selectively repress agonist-mediated nuclear export of HDAC4/5, Rev and NFAT proteins in neonatal rat ventricular myocytes (NRVMs; EC50=2.2 and 3.5nM for GFP-HDAC5 and GFP-HIV Rev) and suppress hypertrophic growth of NRVMs (EC50=52nM for ANF expression inhibition) with negligible effect either on the phosphorylation of HDAC5 or on the kinase activities of P and CaMKII at 1uM.

Synonyms
(Z)-But-2-enedioic acid (4ʹ-bromophenyl)amide (3ʹʹ-chlorophenyl)amide, Chromosome Region Maintenance 1 Protein Inhibitor III, Exportin 1 Inhibitor III, XPO1 Inhibitor III
Molecular Formula
C₁₆H₁₂BrClN₂O₂
Solubility
DMSO (100mg/ml)
Purity
≥95% (HPLC)
Appearance
Supplied as a yellow powder.
Storage and Stability
Lyophilized powder may be stored at 4°C. Stable for 12 months after receipt at 4°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at 4°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Monovich, L., et al. 2009. Biochim Biophys Acta. 1789, 422.
USBio References
No references available
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